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    2020-7-9 · This Test is one qualitative immunochromatographic test for the detection of IGFBP-1 in vaginal secretions. It is intended for use by health care professionals as an aid in the diagnosis of premature rupture of amniotic membranes (prom) in pregnant women where prom is suspected.

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  • [Analysis of cervicovaginal fluid in the diagnosis of ...

    2011-1-1 · In Poland various tests based on the analysis of vaginal pH and a test Actim Prom based on the analysis of IGFBP-1 are available. In clinical practice, approximately 10% of cases of PROM require additional confirmation, which can be difficult, especially in the outpatient setting.

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    2021-7-15 · Insulin growth factor binding protein-1 (IGFBP-1), Interlukin-6 (Il-6), human placental lactogen (HPL), diamino-oxidase or their combinations [6-12]. All these tests have advantages as well as drawbacks [6-11]. Kafali H and Oskuzlerc reported that sensitivity, specificity, positive and negative predictive values were 100% in detecting PROM by ...

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  • INSTRUCTIONS FOR USE

    2021-5-26 · phosphorylated IGFBP-1 (insulin-like growth factor binding protein-1) in cervical secretions during pregnancy. The test is intended for professional use to help predict the risk of preterm or imminent delivery when fetal membranes are intact. A negative test result is a clear indication that the patient will not deliver within 7-14 days.

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    The global preterm birth and PROM testing market size is expected to reach USD 1.3 billion by 2025, according to a new report by Grand View Research, Inc., exhibiting a CAGR of 1.8% during the forecast period. Rising incidence of preterm births, increasing geographical reach by market players, high demand for effective diagnosis of preterm births, and advanced drug delivery devices are ...

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  • Vaginal fluid creatinine for the detection of premature ...

    diagnostic accuracy, especially with passage of time since membrane rupture. However, the gold stand-ard for diagnosis of PROM, amnio-dye test, is inva-sive and carries risks of infection, abruption, and abortion.7 In recent years, researchers have focused on detect-ing various biochemical markers in cervicovaginal dis-charge when ROM occurs.

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    Introduction. The global market size of preterm birth and PROM testing was value at 1.11 billion at 2017 and is expected to reach 1.31 billion by the end of year 2026.The market is estimated to grow at a CAGR of 1.74% over the forecast period.. Market Dynamics. Premature rupture of membranes (PROM) is one of the main cause of preterm births.

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    In Poland various tests based on the analysis of vaginal pH and a test Actim Prom® based on the analysis of IGFBP-1 are available. In clinical practice, approximately 10% of cases of PROM require additional confirmation, which can be difficult, especially in the outpatient setting.

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  • Comment on: guidelines for the management of

    2011-11-24 · In all of these categories, the test based on PAMG-1 (AmniSure ® ROM Test) was superior to that based on IGFBP-1 (Actim ® PROM Test). The finding that the test based on PAMG-1 is more sensitive in its detection of amniotic fluid than that based on IGFBP-1 is particularly relevant for clinical practice as biochemical tests are specifically ...

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  • Preterm premature rupture of the membranes:

    2019-5-1 · In uncertain clinical situations, an immunochromatographic test to detect Insulin-like Growth Factor-Binding Protein-1 (IGFBP-1) or Placenta Alpha 1-Microglobulin (PAMG-1) is recommended to diagnose PROM, although it has not been demonstrated that their use reduces either neonatal or maternal morbidity (professional consensus).

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    1999-8-1 · Insulin-like growth factor binding protein-1 (IGFBP-1; previously also called placental protein-12) is a 25-kD protein synthesized and secreted by the fetal and adult liver and maternal decidua.13, 14 In the maternal circulation, concentration of IGFBP-1 increases during pregnancy, and it is a major protein in the amniotic fluid (AF) from the ...

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    1993-6-30 · A rapid diagnostic method for detecting the rupture of fetal membranes is disclosed. The presence of insulin-like growth factor binding protein 1 (IGFBP-1) in a vaginal secretion sample, resulting from the rupture of fetal membranes, is detected with the aid of at least one specific binding substance for IGFBP-1 .

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    2016-12-7 · AmniSure: The effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests. Research shows that conventional diagnostic tests, such as nitrazine (pH), ferning, pooling and ultrasound can be inaccurate and invasive.

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  • Vaginal Fluid Urea and Creatinine as Indicators of ...

    2020-7-27 · The purpose of the present study was to determine the diagnostic accuracy of vaginal urea and creatinine levels in the detection of premature rupture of membrane (PROM). The Cochrane (central), EMBASE, PubMed, Scopus, and Web of Science were searched for studies published from the inception of the databases up to January 2020. We included published observational full-text articles.

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    2017-7-21 · 1 Dip area 2 Result area 3 Test line 4 Control line STRUCTURE OF CARTRIDGE 5 QR code INTENDED USE Actim Partus 1ngeni test is a qualitative immunochromatographic dipstick test for detecting the presence of phosphorylated IGFBP-1 (insulin-like growth factor binding protein-1) in cervical secretions during pregnancy. The test is

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    A rapid diagnostic method for detecting the rupture of fetal membranes is disclosed. The presence of insulin-like growth factor binding protein 1 (IGFBP-1) in a vaginal secretion sample, resulting from the rupture of fetal membranes, is detected with the aid of at least one specific binding substance for IGFBP-1 .

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    2017-4-26 · This study compared the diagnostic performance characteristics between two commercially-available, immunochromatographic methods for the detection of ROM: 1) a monoclonal immunoassay that detects the PAMG-1 (AmniSure®, QIAGEN N.V., Netherlands), and 2) a monoclonal/polyclonal immunoassay that detects the presence of IGFBP-1 and AFP (ROM Plus®, Clinical Innovations, Salt …

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    Successively, AmniSure (R) test (PAMG-1) without speculum, and then Actim (TM) Prom test (IGFBP-1) during speculum examination were performed during the same visit. Results. Eighty subjects (40 in each group) were included between 25(1/7) to 41(1/7) weeks of gestation.

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    2017-4-26 · This study compared the diagnostic performance characteristics between two commercially-available, immunochromatographic methods for the detection of ROM: 1) a monoclonal immunoassay that detects the PAMG-1 (AmniSure®, QIAGEN N.V., Netherlands), and 2) a monoclonal/polyclonal immunoassay that detects the presence of IGFBP-1 and AFP (ROM Plus®, Clinical Innovations, Salt …

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    ROM Plus detects dual protein markers, AFP and IGFBP-1; ROM Plus is the only PROM test that uses a polyclonal & monoclonal antibody approach; No speculum exam required; No gestational age limit; Reliable diagnosis of PROM allows for gestational age-specific interventions designed to minimize the potential risk of complications to both mother ...

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